FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Atilgan, AR
   Durell, SR
   Jernigan, RL
   Demirel, MC
   Keskin, O
   Bahar, I
AF Atilgan, AR
   Durell, SR
   Jernigan, RL
   Demirel, MC
   Keskin, O
   Bahar, I
TI Anisotropy of fluctuation dynamics of proteins with an elastic network
   model
SO BIOPHYSICAL JOURNAL
LA English
DT Article
ID RETINOL-BINDING PROTEIN; PRINCIPAL COMPONENT ANALYSIS;
   MOLECULAR-DYNAMICS; VIBRATIONAL DYNAMICS; CONCERTED MOTIONS;
   SINGLE-PARAMETER; FOLDED PROTEINS; DOMAIN MOTIONS; ANHARMONICITY;
   CONFORMATIONS
AB Fluctuations about the native conformation of proteins have proven to be suitably reproduced with a simple elastic network model, which has shown excellent agreement with a number of different properties for a wide variety of proteins. This scalar model simply investigates the magnitudes of motion of individual residues in the structure. To use the elastic model approach further for developing the details of protein mechanisms, it becomes essential to expand this model to include the added details of the directions of individual residue fluctuations. In this paper a new tool is presented for this purpose and applied to the retinol-binding protein, which indicates enhanced flexibility in the region of entry to the ligand binding site and for the portion of the protein binding to its carrier protein.
C1 Bogazici Univ, Sch Engn, TR-80815 Bebek, Istanbul, Turkey.
   Bogazici Univ, Ctr Polymer Res, TR-80815 Bebek, Istanbul, Turkey.
   TUBITAK, Adv Polymer Mat Res Ctr, TR-80815 Bebek, Istanbul, Turkey.
   NCI, MSS, LECB, DBS,NIH, Bethesda, MD 20892 USA.
   Sci Applicat Int Corp, NIH, Frederick, MD 20892 USA.
RP Jernigan, RL (reprint author), NCI, MSS, LECB, DBS,NIH, Rm B-116,Bldg 12B, Bethesda, MD 20892 USA.
RI Atilgan, Ali Rana/A-7805-2011; Demirel, Melik/E-4495-2010; Jernigan,
   Robert/A-5421-2012; Demirel, Melik/E-3775-2016
NR 49
TC 773
Z9 790
U1 8
U2 60
PU BIOPHYSICAL SOCIETY
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0006-3495
J9 BIOPHYS J
JI Biophys. J.
PD JAN
PY 2001
VL 80
IS 1
BP 505
EP 515
PG 11
WC Biophysics
SC Biophysics
GA 396QH
UT WOS:000166647700043
PM 11159421
ER

EF